Endocrine Abstracts

Gynecomastia (Gm) is defined as increased mammary gland size in male and must be distinguished from lipomastia. Mammary tissue is present in children of both sexes. The gland does not develop when androgens (A) prevail over estrogens (E). In men molar ratio of plasma testosterone to estradiol is about 300 to 1. Any deviation from this ratio, be it through diminished A or increased E, can lead to Gm. Testes maturation requires both A and E and palpable mammary tissue is present...

AbstractThe aim of our research was to find different from estradiol steroid hormones that changes in their concentrations may be risk factors of coronary artery disease (CAD) in women.Material and methods:YM-CAD-38 menstruating women in the age of 42.6±3.4 years with past myocardial infarction and angiographically proven arteriosclerosis. YM-H- 15 healthy menstruating women in the age of 41.1&#17...

Aim: To define concentrations (conc) of steroid hormones in patients (pts) with preserved gonadal function, suffering from coronary artery disease (CAD), and to assess their relations to patients’ weight.Material: Pts with coronarographically proved CAD: C-W group (gr)-52 women (W) in the age 43±3 years, with stable menstrual rhythm, C-M gr-46 men (M) in the age 52±6 years. Healthy volunteers: H-W gr-15 W (H-W) in the age 41±4 years, ...

Aim: Assessment of possible role of arginine vasopressin (AVP) and aldosterone (Ald), hormones managing blood pressure and water-electrolyte balance, for clinical state and survival of patents after cardiac arrest (CA).Material and methods: Fifty-two patients after CA in the age 62±13 years, 29 patients after out-of-hospital CA, 23 after in-hospital CA. Twenty-eight patients died after CA (CA-D), 24 survived (CA-S). In each day after CA clinical sta...

Aim: To assess concentration (conc) of arginine vasopressin (AVP) and conc of N- terminated naturetic propeptyde type B (NTpBNP) in patients (pts) after cardiac arrest (CA) and their role for clinical state of pts after CA.Material: 52 pts after CA, 36 men and 16 women, in the age 62±13 years. CA was caused by ventricular fibrillation in 31 cases, by asystolia in 15 and by pulseless electrical activity in 6. 28 pts died after CA (P-CA-D), 24 survive...

Background: During ageing, total testosterone (TT) declines and SHBG increases, resulting in a greater decline of free testosterone (FT) compared to TT. However, guidelines suggest using TT to diagnose androgen deficiency and to reserve FT only for men with borderline TT. We investigated if isolated low FT or isolated low TT was associated with androgen-related endpoints in healthy men.Methods: 3369 community-dwelling men, aged 40–79, were included....

Introduction: Primary hypogonadism (PHG, testosterone <10.5 nmol/l and LH >9.5 U/l) without a recognisable cause affects ~2% of community-dwelling middle-aged and older men. We sought to identify the clinical significance of, and risk factors for, this apparently age-related hypogonadal state.Methods/design: The European Male Ageing Study (EMAS) is a prospective observational cohort survey of 3.369 community-dwelling men aged 40–79 in eight ...